Kumar says. Researchers want to build on the success of these treatments and further reduce the chance that the cancer will return. MSK has completed a phase II clinical trial to see whether incorporating a drug called lenalidomide into chemotherapy treatment will help prevent MCL from returning. Lenalidomide affects the immune system in a way that helps to stop cancer cells from growing. In the trial, lenalidomide is given along with R-CHOP chemotherapy, followed by rituximab and cytarabine. Then lenalidomide and rituximab are given as maintenance treatment after chemotherapy.
MCL that returns, or recurs, has been hard to treat because it is more resistant to chemotherapy. Two categories of drugs that are highly effective for the treatment of recurrent MCL are kinase inhibitors and BCL-2 inhibitors. Another strategy involves combining ibrutinib with a second kinase inhibitor called buparlisib that targets a different protein.
This triggers an immune response by directing the T cells to kill the cancerous B cells. Another trial is investigating chimeric antigen receptor CAR T cell therapy. The hope is that the treatment will also work against MCL. Learn more about clinical trials at MSK for people with mantle cell lymphoma. My husband has been newly diagnosed with MCL. We have a consultation with Dr.
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Non-Hodgkin lymphoma: Treatment advances for diffuse large B-cell lymphoma
Health news in pictures Show all A vaping-related lung disease has claimed the lives of 11 people in the US in recent weeks. Researchers in the US claim to have overcome one of the major hurdles to cultivating human follicles from stem cells. The new system allows cells to grow in a structured tuft and emerge from the skin. A study in the journal Scientific Reports suggests that a dose of nature of just two hours a week is associated with better health and psychological wellbeing. Exposure to air from traffic-clogged streets could leave women with fewer years to have children, a study has found.
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